Therapeutic Drug Monitoring  

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Beta-lactam and aminoglyoside user guide

Vancomycin user guide

Original articles

S.G. Wicha, M.G. Kees, A. Solms, I.K. Minichmayr, A. Kratzer, C. Kloft
TDMx – a novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine.
Int. J. Antimicrob. Agents. 45: 442-444 (2015).
doi: 10.1016/j.ijantimicag.2014.12.010

M.A. Barras, D. Serisier, S. Hennig, K. Jess, R.L.G. Norris
Bayesian Estimation of Tobramycin Exposure in Patients with Cystic Fibrosis
Antimicrob. Agents Chemother. 60: 6698-6702 (2016).
doi:  10.1128/AAC.01131-16

A. Broeker, M. Nardecchia, K.P. Klinker, H. Derendorf, R.O. Day, D.J. Marriott, J.E. Carland, S.L. Stocker, S.G. Wicha
Towards precision dosing of vancomycin: A systematic evaluation of pharmacometric models for Bayesian forecasting.
Clin. Microbiol. Infect. 25: 1286e1-e7 (2019). 
doi:  10.1016/j.cmi.2019.02.029

C.B. Cunio, D.W. Uster, J.E. Carland, H. Buscher, Z. Liu, J. Brett, M. Stefani, G.R.D. Jones, R.O. Day, S..G. Wicha, S.L. Stocker
Towards precision dosing of vancomycin in critically ill patients: A evaluation of the predictive performanceof pharmacometric models in ICU patients.
Clin. Microbiol. Infect. (ahead of print) (2020). 
doi:  10.1016/j.cmi.2020.07.005

D.W. Uster, S.L. Stocker, J.E. Carland, J. Brett, D.J. E. Marriott, R.O. Day, S.G. Wicha
A Model Averaging/Selection Approach Improves the Predictive Performance of Model-Informed Precision Dosing: Vancomycin as a Case Study.
Clin. Pharmacol. Ther. 109: 175-183 (2021).
doi: 10.1002/cpt.2065

S.G. Wicha, A.G. Märtson, E.I. Nielsen, B.C.P. Koch, L.E. Friberg, J.W. Alffenaar, I.K. Minichmayr
From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics.
Clin. Pharmacol. Ther. 109: 928-941 (2021).

S.G. Wicha
TDMx: A bedside web-based support tool to guide intermittent vs. continuous infusion of beta-lactams.
25 th Meeting of the International Society of Antiifective Pharmacology, San Diego, USA 21 September 2015.

S.G. Wicha
TDMx – a web-based paradagim for personalized TDM.
PKUK 2015, Chester, UK, 18 - 21 November 2015.